{"id":4172,"date":"2025-03-12T18:20:03","date_gmt":"2025-03-12T18:20:03","guid":{"rendered":"https:\/\/entrogen.com\/web4\/?post_type=product&p=4172"},"modified":"2025-06-23T18:13:36","modified_gmt":"2025-06-23T18:13:36","slug":"npm1-one-step-mrd-kit","status":"publish","type":"product","link":"https:\/\/entrogen.com\/web4\/product\/npm1-one-step-mrd-kit\/","title":{"rendered":"NPM1 One-Step MRD Kit"},"content":{"rendered":"[et_pb_section fb_built=”1″ admin_label=”Section” _builder_version=”4.27.2″ _module_preset=”default” custom_padding=”6px||4px|||” collapsed=”off” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” width=”100%” custom_padding=”0px||0px||false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_wc_breadcrumb admin_label=”Woo Breadcrumbs” _builder_version=”4.16″ global_colors_info=”{}”][\/et_pb_wc_breadcrumb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ specialty=”on” _builder_version=”4.27.2″ _module_preset=”default” custom_padding=”0px||9px|||” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_wc_images admin_label=”Woo Product Images” _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”|||-98px||” custom_padding=”|||23px||” global_colors_info=”{}”][\/et_pb_wc_images][\/et_pb_column][et_pb_column type=”2_3″ specialty_columns=”2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_row_inner column_structure=”1_2,1_2″ _builder_version=”4.27.2″ _module_preset=”default” custom_padding=”|0px||||” global_colors_info=”{}”][et_pb_column_inner type=”1_2″ saved_specialty_column_type=”2_3″ _builder_version=”4.27.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_wc_title _builder_version=”4.27.2″ _module_preset=”default” header_font_size=”27px” custom_margin=”|-164px||||” global_colors_info=”{}”][\/et_pb_wc_title][\/et_pb_column_inner][et_pb_column_inner type=”1_2″ saved_specialty_column_type=”2_3″ _builder_version=”4.27.2″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column_inner saved_specialty_column_type=”2_3″ _builder_version=”4.27.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_wc_description admin_label=”Woo Product Short Description” _builder_version=”4.27.4″ custom_margin=”-8px|||||” global_colors_info=”{}”][\/et_pb_wc_description][et_pb_wc_meta show_sku=”off” admin_label=”Woo Product Meta” _builder_version=”4.27.2″ global_colors_info=”{}”][\/et_pb_wc_meta][et_pb_button button_url=”https:\/\/entrogen.com\/web4\/product-information-request-form\/” url_new_window=”on” button_text=”Request More Information” button_alignment=”left” admin_label=”Button” _builder_version=”4.27.4″ _module_preset=”default” custom_button=”on” button_text_size=”13px” button_text_color=”#FFFFFF” button_bg_color=”#476e8d” button_border_color=”RGBA(255,255,255,0)” background_layout=”dark” custom_margin=”30px|||||” global_colors_info=”{}”][\/et_pb_button][\/et_pb_column_inner][\/et_pb_row_inner][\/et_pb_column][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ custom_padding=”0px||||false|false” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” width=”100%” custom_padding=”6px|||||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_tabs admin_label=”Tabs” _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”24px|||||” custom_padding=”|30px|60px|||” global_colors_info=”{}”][et_pb_tab title=”Product Overview” _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”]\n

Mutations in the NPM1 gene, one of the most common genetic alterations in acute myeloid leukemia (AML), serve as key biomarkers for disease detection and monitoring. Studies have shown that NPM1 mutations, particularly in Type A, B, and D transcripts, are critical for assessing minimal residual disease (MRD) and predicting relapse risk. As a result, molecular testing for NPM1 mutations has become an essential component of AML management.<\/p>\n

The NPM1 Quantitative MRD Assay is a real-time PCR-based test that utilizes mutant-specific amplification and fluorescent hydrolysis probes to ensure precise and reproducible detection. This highly sensitive assay detects NPM1 mutations at a 0.001% (5-log reduction) sensitivity level, providing quantitative MRD assessment in under two hours. The assay is designed for use with RNA extracted from peripheral blood or bone marrow samples, providing researchers with a reliable tool for studying minimal residual disease in acute myeloid leukemia.<\/p>\n

The assay is able to identify minimal residual disease with exceptional precision. In tests, Type A mutations remain detectable even at the 0.001% (5-log reduction) level. This level of sensitivity is crucial for early relapse monitoring and research applications, ensuring that even minute traces of the mutation can be consistently detected.<\/p>\n

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The NPM1 One-Step MRD Kit follows a simple and easy to use process. The assay is a one-step reverse transcription and qPCR assay that detects the presence of Type A, B and D transcripts in RNA isolated from peripheral blood or bone marrow samples can be completed in less than 2 hours.<\/p>\n

EntroGen\u02bcs NPM1 mutation screening panel requires a real-time PCR instrument capable of detecting FAM and VIC fluorescent probes. This test includes reagents required for PCR amplification\/detection, as well as validated reaction controls.<\/p>\n

Columns and reagents for DNA isolation are not included.<\/p>\n

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Click to download lot-specific quality control data for your product:<\/p>\n

Download<\/span><\/a><\/a><\/u><\/p>\n

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Cat Number: NPM1-QRT32<\/strong><\/p>\n

The NPM1 One-Step MRD Assay is a PCR-based test that detects Type A, B, and D mutations in the NPM1 gene, a key biomarker in acute myeloid leukemia (AML).<\/p>\n

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