{"id":4264,"date":"2025-03-26T17:33:33","date_gmt":"2025-03-26T17:33:33","guid":{"rendered":"https:\/\/entrogen.com\/web4\/?post_type=product&#038;p=4264"},"modified":"2025-08-04T23:18:48","modified_gmt":"2025-08-04T23:18:48","slug":"leukemia-translocation-panel","status":"publish","type":"product","link":"https:\/\/entrogen.com\/web4\/product\/leukemia-translocation-panel\/","title":{"rendered":"Leukemia Translocation Panel for Real-Time PCR"},"content":{"rendered":"[et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Section&#8221; _builder_version=&#8221;4.27.2&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;6px||4px|||&#8221; collapsed=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; width=&#8221;100%&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; 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_module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column_inner saved_specialty_column_type=&#8221;2_3&#8243; _builder_version=&#8221;4.27.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_wc_description admin_label=&#8221;Woo Product Short Description&#8221; _builder_version=&#8221;4.27.4&#8243; custom_margin=&#8221;-8px|||||&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_wc_description][et_pb_wc_meta show_sku=&#8221;off&#8221; admin_label=&#8221;Woo Product Meta&#8221; _builder_version=&#8221;4.27.2&#8243; global_colors_info=&#8221;{}&#8221;][\/et_pb_wc_meta][et_pb_button button_url=&#8221;https:\/\/entrogen.com\/web4\/product-information-request-form\/&#8221; button_text=&#8221;Request More Information&#8221; button_alignment=&#8221;left&#8221; admin_label=&#8221;Button&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; custom_button=&#8221;on&#8221; button_text_size=&#8221;13px&#8221; button_text_color=&#8221;#FFFFFF&#8221; button_bg_color=&#8221;#476e8d&#8221; button_border_color=&#8221;RGBA(255,255,255,0)&#8221; background_layout=&#8221;dark&#8221; custom_margin=&#8221;30px|||||&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_button][\/et_pb_column_inner][\/et_pb_row_inner][\/et_pb_column][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;0px||||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; custom_padding=&#8221;6px|||||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.27.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_tabs admin_label=&#8221;Tabs&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;24px|||||&#8221; custom_padding=&#8221;|30px|60px|||&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;][et_pb_tab title=&#8221;Product Overview&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]\n<p data-start=\"179\" data-end=\"784\">Chromosomal translocations are among the most significant genetic alterations in leukemia and serve as key biomarkers for disease classification, prognosis, and the development of targeted therapies. These translocations often result in the fusion of enhancer\/promoter regions or coding sequences from two distinct genes, leading to abnormal gene expression, disruption of normal cellular function, or oncogenic activity that drives leukemogenesis. Specific fusion genes are highly prevalent in both pediatric and adult leukemias and are closely associated with disease progression and treatment response.<\/p>\n<p data-start=\"786\" data-end=\"1379\">Accurate detection and identification of fusion gene transcripts in blood or bone marrow samples are essential for diagnosis, prognostic assessment, and treatment stratification in acute lymphoblastic leukemia (ALL), acute promyelocytic leukemia (APL), and acute myeloid leukemia (AML). Beyond initial detection, quantitative molecular monitoring of these fusion transcripts allows for the identification of minimal residual disease (MRD) and early signs of molecular relapse, supporting timely adjustments to therapeutic approaches<\/p>\n<p data-start=\"1381\" data-end=\"1817\">The Leukemia Translocation Panel v2 (LEUKMP) is a quantitative real-time PCR-based assay designed for the sensitive detection and monitoring of 11 fusion gene variants associated with six key chromosomal translocations in ALL, AML, and APL. The assay includes validated primer-probe sets and is compatible with major multi-channel real-time PCR platforms, supporting both diagnostic research and longitudinal MRD monitoring.<\/p>\n<p>A low positive control for the Leukemia Translocation Panel is available and sold separately to support assay validation and performance monitoring.<\/p>\n<p>Additionally, one-step RT-PCR kits for individual fusion gene transcripts are available separately for molecular monitoring during treatment.<\/p>\n<table style=\"height: 310px; width: 437px;\" border=\"1\" width=\"353\">\n<tbody>\n<tr style=\"height: 24px;\">\n<td style=\"height: 24px; width: 77.7344px;\"><strong>Disease<\/strong><\/td>\n<td style=\"height: 24px; width: 149.703px;\"><strong>Translocations<\/strong><\/td>\n<td style=\"height: 24px; width: 187.562px;\"><strong>Fusion Transcripts<\/strong><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"height: 96px; width: 77.7344px;\" rowspan=\"4\">ALL<\/td>\n<td style=\"height: 24px; width: 149.703px;\">t(1;19)<\/td>\n<td style=\"height: 24px; width: 187.562px;\">E2A\/PBX1 (e13\/e2)<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"height: 24px; width: 149.703px;\">t(12;21)<\/td>\n<td style=\"height: 24px; width: 187.562px;\">TEL\/AML1 (e5\/e2)<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"height: 48px; width: 149.703px;\" rowspan=\"2\">t(4;11)<\/td>\n<td style=\"height: 24px; width: 187.562px;\">MLL\/AF4 (e9\/e5)<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"height: 24px; width: 187.562px;\">MLL\/AF4 (e9\/e4)<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"height: 72px; width: 77.7344px;\" rowspan=\"3\">APL<\/td>\n<td style=\"height: 72px; width: 149.703px;\" rowspan=\"3\">t(15;17)<\/td>\n<td style=\"height: 24px; width: 187.562px;\">PML\/RAR\u03b1 (bcr1)<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"height: 24px; width: 187.562px;\">PML\/RAR\u03b1 (bcr2)<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"height: 24px; width: 187.562px;\">PML\/RAR\u03b1 (bcr3)<\/td>\n<\/tr>\n<tr style=\"height: 48px;\">\n<td style=\"height: 168px; width: 77.7344px;\" rowspan=\"4\">AML<\/td>\n<td style=\"height: 144px; width: 149.703px;\" rowspan=\"3\">Inv 16<\/td>\n<td style=\"height: 48px; width: 187.562px;\">CBFB\/MYH11 (A type)<\/td>\n<\/tr>\n<tr style=\"height: 48px;\">\n<td style=\"height: 48px; width: 187.562px;\">CBFB\/MYH11 (D type)<\/td>\n<\/tr>\n<tr style=\"height: 48px;\">\n<td style=\"height: 48px; width: 187.562px;\">CBFB\/MYH11 (E type)<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"height: 24px; width: 149.703px;\">t(8;21)<\/td>\n<td style=\"height: 24px; width: 187.562px;\">AML1\/ETO (e5\/e12)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<a href=\"https:\/\/entrogen.com\/web4\/product-information-request-form\/\" class=\"su-button su-button-style-default\" style=\"color:#FFFFFF;background-color:#2D89EF;border-color:#246ec0;border-radius:5px\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color:#FFFFFF;padding:0px 16px;font-size:13px;line-height:26px;border-color:#6cadf4;border-radius:5px;text-shadow:none\"> For More Information<\/span><\/a>\n<p>&nbsp;<\/p>\n[\/et_pb_tab][et_pb_tab title=&#8221;Workflow&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]\n<p>The Leukemia Translocation Panel follows a simple and easy to use process. It can be completed in 2 hours with only 15 minutes of hands-on time<\/p>\n<p>EntroGen\u02bcs leukemia transloacation panel requires a real-time PCR instrument capable of detecting FAM, VIC, ROX, and CY5 fluorescent probes. This test includes reagents required for PCR amplification\/detection, as well as validated reaction controls.<\/p>\n<p>The panel does not include reagents or columns for isolation of total RNA from blood or bone marrow.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-4265 alignnone size-medium\" src=\"https:\/\/entrogen.com\/web4\/wp-content\/uploads\/2025\/03\/LEUKMP-RT24-Load-Samples-267x300.png\" alt=\"\" width=\"267\" height=\"300\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"wp-image-4164 alignnone size-medium\" src=\"https:\/\/entrogen.com\/web4\/wp-content\/uploads\/2025\/03\/Arrow-right-sized-74x300.png\" alt=\"\" width=\"74\" height=\"300\" srcset=\"https:\/\/entrogen.com\/web4\/wp-content\/uploads\/2025\/03\/Arrow-right-sized-74x300.png 74w, https:\/\/entrogen.com\/web4\/wp-content\/uploads\/2025\/03\/Arrow-right-sized.png 150w\" sizes=\"(max-width: 74px) 100vw, 74px\" \/><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/entrogen.com\/web4\/wp-content\/uploads\/2025\/03\/LEUKMP-RT24-Run-in-PCR-1-267x300.png\" width=\"267\" height=\"300\" alt=\"\" class=\"wp-image-4308 alignnone size-medium\" \/>\u00a0\u00a0<img loading=\"lazy\" decoding=\"async\" class=\"wp-image-4164 alignnone size-medium\" src=\"https:\/\/entrogen.com\/web4\/wp-content\/uploads\/2025\/03\/Arrow-right-sized-74x300.png\" alt=\"\" width=\"74\" height=\"300\" srcset=\"https:\/\/entrogen.com\/web4\/wp-content\/uploads\/2025\/03\/Arrow-right-sized-74x300.png 74w, https:\/\/entrogen.com\/web4\/wp-content\/uploads\/2025\/03\/Arrow-right-sized.png 150w\" sizes=\"(max-width: 74px) 100vw, 74px\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"wp-image-4230 alignnone size-medium\" src=\"https:\/\/entrogen.com\/web4\/wp-content\/uploads\/2025\/03\/Analyze-Results-1-267x300.png\" alt=\"\" width=\"267\" height=\"300\" \/><\/p>\n[\/et_pb_tab][et_pb_tab title=&#8221;Resources&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]\n<table border=\"0\" style=\"width: 100%; border-collapse: collapse; border-style: none;\">\n<tbody>\n<tr>\n<td style=\"width: 3.17757%;\"><a href=\"https:\/\/entrogen.com\/web4\/wp-content\/uploads\/2025\/08\/Entrogen_AMP2023_v2.pdf\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/entrogen.com\/web4\/wp-content\/uploads\/2025\/08\/LEUKMP-Poster-150x150.png\" width=\"150\" height=\"150\" alt=\"\" class=\"wp-image-5200 alignnone size-thumbnail\" \/><\/a><\/td>\n<td style=\"width: 16.8224%;\"><a href=\"https:\/\/entrogen.com\/web4\/wp-content\/uploads\/2025\/08\/Entrogen_AMP2023_v2.pdf\" target=\"_blank\" rel=\"noopener\"><strong>Analytical Utility of a One-Step cDNA Synthesis and Real-Time PCR Assay for<\/strong><\/a><br \/><strong><a href=\"https:\/\/entrogen.com\/web4\/wp-content\/uploads\/2025\/08\/Entrogen_AMP2023_v2.pdf\" target=\"_blank\" rel=\"noopener\">the Rapid Detection of Common Fusion Genes in Acute Leukemia<\/a><\/strong><br \/><a href=\"https:\/\/entrogen.com\/web4\/wp-content\/uploads\/2025\/08\/Entrogen_AMP2023_v2.pdf\" target=\"_blank\" rel=\"noopener\">Butcher DT1,2, Haasen A1, Wilson K1, Piech C1, Demczuk S1,2, McCready ME1,2<\/a><br \/><a href=\"https:\/\/entrogen.com\/web4\/wp-content\/uploads\/2025\/08\/Entrogen_AMP2023_v2.pdf\" target=\"_blank\" rel=\"noopener\">1. Genetics Laboratory, Hamilton Regional Laboratory Medicine Program, Hamilton, Canada<\/a><br \/><a href=\"https:\/\/entrogen.com\/web4\/wp-content\/uploads\/2025\/08\/Entrogen_AMP2023_v2.pdf\" target=\"_blank\" rel=\"noopener\">2. Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p>Click to download lot-specific quality control data for your product:<\/p>\n<p><u><a href=\"https:\/\/entrogen.com\/coa\"><a href=\"https:\/\/entrogen.com\/coa\" class=\"su-button su-button-style-default\" style=\"color:#FFFFFF;background-color:#2D89EF;border-color:#246ec0;border-radius:5px\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color:#FFFFFF;padding:0px 16px;font-size:13px;line-height:26px;border-color:#6cadf4;border-radius:5px;text-shadow:none\"> Download<\/span><\/a><\/a><\/u><\/p>\n<p>&nbsp;<\/p>\n[\/et_pb_tab][\/et_pb_tabs][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.27.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.27.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_wc_related_products include_categories=&#8221;current&#8221; show_price=&#8221;off&#8221; show_rating=&#8221;off&#8221; show_sale_badge=&#8221;off&#8221; _builder_version=&#8221;4.27.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_wc_related_products][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_section]\n","protected":false},"excerpt":{"rendered":"<p>Cat Number: <strong>LEUKMP-RT24<\/strong><\/p>\n<p>The Leukemia Translocation Panel is a one-step reverse transcription and qPCR assay designed to quantitatively detect 6 fusion genes commonly found in childhood and adult leukemias.<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li>One \u2013step cDNA synthesis<\/li>\n<li>Detects 11 different fusion genes<\/li>\n<li>24 tests per kit<\/li>\n<li>Less than 2-hour turnaround time<\/li>\n<li>Works with bone marrow or blood<\/li>\n<li>2 Reactions per sample<\/li>\n<li>Low positive control available to <span class=\"T286Pc\" data-processed=\"true\">assist in assay validation and monitoring<\/span><\/li>\n<li>For research use (RUO) in the U.S<\/li>\n<li>For in vitro diagnostic use (IVD) in the European Union<\/li>\n<\/ul>\n","protected":false},"featured_media":4934,"template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"[su_tabs][su_tab title=\"Overview\" disabled=\"no\" anchor=\"\" url=\"\" target=\"\" class=\"\"]\r\n\r\nMutations in the KRAS gene, commonly found in metastatic colorectal cancer (mCRC), lung adenocarcinoma, and thyroid cancer, can make tumors resistant to anti-EGFR treatments. Studies show that mutations in exons 2, 3, and 4 of the KRAS and NRAS genes reduce the effectiveness of these therapies, leading experts, including the American Society of Clinical Oncology (ASCO), to recommend genetic screening before treatment.\r\n\r\nThe RAS mutation analysis real-time assay utilizes allele-specific PCR, ensuring accurate detection using fluorescent hydrolysis probes. The panel is a qualitative test that detects somatic mutations found in exons 2, 3, and 4 of KRAS and NRAS genes. Below is a list of mutations detected by this kit.\r\n\r\nThe RAS Mutation Screening Panel identifies the presence of the mutations in a total of 8 reactions per sample. The test does not distinguish between mutations within each group.\r\n\r\n*A complementary add-on reaction that distinguishes KRAS G12C from other codon 12 mutations is available, upon request.\r\n\r\n<sup><img class=\"alignnone size-medium wp-image-4077\" src=\"http:\/\/entrogen.com\/web4\/wp-content\/uploads\/2024\/11\/KRAS-Mutation-Chart-300x128.png\" alt=\"\" width=\"300\" height=\"128\" \/>\r\n<\/sup><sup>1<\/sup> My Cancer Genome; www.mycancergenome.org (Colorectal Carcinoma, Colorectal Adenocarcinoma)\r\n\r\n[\/su_tab]\r\n[su_tab title=\"Workflow\" disabled=\"no\" anchor=\"\" url=\"\" target=\"blank\" class=\"\"]\r\n\r\nProduct Workflow\r\n\r\n[\/su_tab]\r\n[su_tab title=\"Resources\" disabled=\"no\" anchor=\"\" url=\"\" target=\"blank\" class=\"\"]\r\n\r\n&nbsp;\r\n\r\n&nbsp;\r\n\r\n<a href=\"http:\/\/entrogen.com\/web4\/videos\/ras.htm\">http:\/\/entrogen.com\/web4\/videos\/ras.htm<\/a>\r\n\r\n[\/su_tab][\/su_tabs]","_et_gb_content_width":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false},"product_brand":[],"product_cat":[58],"product_tag":[],"class_list":{"0":"post-4264","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-leukemia","8":"first","9":"instock","10":"shipping-taxable","11":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/entrogen.com\/web4\/wp-json\/wp\/v2\/product\/4264","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/entrogen.com\/web4\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/entrogen.com\/web4\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/entrogen.com\/web4\/wp-json\/wp\/v2\/media\/4934"}],"wp:attachment":[{"href":"https:\/\/entrogen.com\/web4\/wp-json\/wp\/v2\/media?parent=4264"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/entrogen.com\/web4\/wp-json\/wp\/v2\/product_brand?post=4264"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/entrogen.com\/web4\/wp-json\/wp\/v2\/product_cat?post=4264"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/entrogen.com\/web4\/wp-json\/wp\/v2\/product_tag?post=4264"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}