{"id":4333,"date":"2025-04-01T15:53:57","date_gmt":"2025-04-01T15:53:57","guid":{"rendered":"https:\/\/entrogen.com\/web4\/?post_type=product&p=4333"},"modified":"2025-06-23T17:37:13","modified_gmt":"2025-06-23T17:37:13","slug":"thyroid-cancer-fusion-gene-detection-kit","status":"publish","type":"product","link":"https:\/\/entrogen.com\/web4\/product\/thyroid-cancer-fusion-gene-detection-kit\/","title":{"rendered":"Thyroid Cancer Fusion Gene Detection Kit"},"content":{"rendered":"[et_pb_section fb_built=”1″ admin_label=”Section” _builder_version=”4.27.2″ _module_preset=”default” custom_padding=”6px||4px|||” collapsed=”off” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” width=”100%” custom_padding=”0px||0px||false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_wc_breadcrumb admin_label=”Woo Breadcrumbs” _builder_version=”4.16″ global_colors_info=”{}”][\/et_pb_wc_breadcrumb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ specialty=”on” _builder_version=”4.27.2″ _module_preset=”default” custom_padding=”0px||9px|||” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_wc_images _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”|||-98px||” custom_padding=”|||23px||” global_colors_info=”{}”][\/et_pb_wc_images][\/et_pb_column][et_pb_column type=”2_3″ specialty_columns=”2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_row_inner column_structure=”1_2,1_2″ _builder_version=”4.27.2″ _module_preset=”default” custom_padding=”|0px||||” global_colors_info=”{}”][et_pb_column_inner type=”1_2″ saved_specialty_column_type=”2_3″ _builder_version=”4.27.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_wc_title _builder_version=”4.27.2″ _module_preset=”default” header_font_size=”27px” custom_margin=”|-164px||||” global_colors_info=”{}”][\/et_pb_wc_title][\/et_pb_column_inner][et_pb_column_inner type=”1_2″ saved_specialty_column_type=”2_3″ _builder_version=”4.27.2″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner _builder_version=”4.27.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_column_inner saved_specialty_column_type=”2_3″ _builder_version=”4.27.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_wc_description admin_label=”Woo Product Short Description” _builder_version=”4.27.4″ custom_margin=”-8px|||||” global_colors_info=”{}”][\/et_pb_wc_description][et_pb_wc_meta show_sku=”off” admin_label=”Woo Product Meta” _builder_version=”4.27.2″ global_colors_info=”{}”][\/et_pb_wc_meta][et_pb_button button_url=”https:\/\/entrogen.com\/web4\/product-information-request-form\/” button_text=”Request More Information” button_alignment=”left” admin_label=”Button” _builder_version=”4.27.4″ _module_preset=”default” custom_button=”on” button_text_size=”13px” button_text_color=”#FFFFFF” button_bg_color=”#476e8d” button_border_color=”RGBA(255,255,255,0)” background_layout=”dark” custom_margin=”30px|||||” global_colors_info=”{}”][\/et_pb_button][\/et_pb_column_inner][\/et_pb_row_inner][\/et_pb_column][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ custom_padding=”0px||||false|false” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” width=”100%” custom_padding=”6px|||||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_tabs admin_label=”Tabs” _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”24px|||||” custom_padding=”|30px|60px|||” global_colors_info=”{}”][et_pb_tab title=”Product Overview” _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”]\n

Chromosomal translocations involving RET\/PTC1, RET\/PTC3, and PAX8\/PPAR\u03b3 are key oncogenic drivers in thyroid cancer, playing a crucial role in tumor initiation and progression. These fusion genes are particularly associated with papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC), and their detection is essential for differentiating malignant thyroid tumors from benign nodules.\u00a0<\/p>\n

The Thyroid Cancer Fusion Gene Detection Kit is a real-time PCR-based assay designed for the sensitive and specific detection of RET\/PTC1, RET\/PTC3, and PAX8\/PPAR\u03b3 (PAX8 exon 7 and exon 9 variants) fusion genes. This assay integrates first-strand cDNA synthesis and simultaneous amplification of fusion and reference genes in a single-step reaction, streamlining the workflow and reducing processing time.<\/p>\n

The kit is optimized for use with total RNA isolated from fine needle aspirates (FNA), fresh-frozen tissues, cell lines, and formalin-fixed paraffin-embedded (FFPE) samples.<\/p>\n[\/et_pb_tab][et_pb_tab title=”Workflow” _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”]\n

The Thyroid Cancer Fusion Gene Detection Kit follows a simple and easy to use process. It can be completed in 2 hours and follows a simple straightforward process.<\/p>\n

EntroGen\u02bcs Thyroid Fusion Gene Detection Kit requires a real-time PCR instrument capable of detecting FAM and VIC fluorescent probes. This test includes reagents required for PCR amplification\/detection, as well as validated reaction controls.<\/p>\n

Columns and reagents for RNA isolation are not included.<\/p>\n

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<\/a><\/p>\n\n\n\n\n
\"\"<\/a><\/td>\nDifferent Qualifiers of AUS\/FLUS Thyroid FNA Have Distinct BRAF, RAS, RET\/PTC and PAX8\/PPARg Alterations.<\/strong> Claudio Bellevicine MD, PhD, Roberta Sgariglia BS, Ilaria Migliatico MD, Elena Vigliar MD, PhD., Melania D\u2019Anna MD, PhD, Maria Antonia Nacchio BS, Nicola Serra PhD, Umberto Malapelle PhD, Massimo Bongiovanni MD, PhD, Giancarlo Troncone MD, PhD. 2018 Feb 22.\u00a0<\/a><\/td>\n<\/tr>\n
\"\"<\/td>\n\u201cMutation Analysis Significantly Improves the Diagnostic Utility and Patient Management of Cytologically Indeterminate Thyroid Nodules\u201d <\/strong>\u2013 Talwalkar, SS<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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Cat Number: THRNA-RT32<\/strong><\/p>\n

The Thyroid Cancer Fusion Gene Detection Kit is a PCR-based assay that detects RET\/PTC1, RET\/PTC3, and PAX8\/PPAR\u03b3 fusion genes, which are associated with thyroid cancer diagnosis, prognosis, and targeted therapy selection.<\/p>\n

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