{"id":4342,"date":"2025-04-01T18:26:55","date_gmt":"2025-04-01T18:26:55","guid":{"rendered":"https:\/\/entrogen.com\/web4\/?post_type=product&p=4342"},"modified":"2025-06-23T17:34:43","modified_gmt":"2025-06-23T17:34:43","slug":"lung-cancer-rna-panel","status":"publish","type":"product","link":"https:\/\/entrogen.com\/web4\/product\/lung-cancer-rna-panel\/","title":{"rendered":"Lung Cancer RNA Panel"},"content":{"rendered":"[et_pb_section fb_built=”1″ admin_label=”Section” _builder_version=”4.27.2″ _module_preset=”default” custom_padding=”6px||4px|||” collapsed=”off” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” width=”100%” custom_padding=”0px||0px||false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_wc_breadcrumb admin_label=”Woo Breadcrumbs” _builder_version=”4.16″ global_colors_info=”{}”][\/et_pb_wc_breadcrumb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ specialty=”on” _builder_version=”4.27.2″ _module_preset=”default” custom_padding=”0px||9px|||” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_wc_images _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”|||-98px||” custom_padding=”|||23px||” global_colors_info=”{}”][\/et_pb_wc_images][\/et_pb_column][et_pb_column type=”2_3″ specialty_columns=”2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_row_inner column_structure=”1_2,1_2″ _builder_version=”4.27.2″ _module_preset=”default” custom_padding=”|0px||||” global_colors_info=”{}”][et_pb_column_inner type=”1_2″ saved_specialty_column_type=”2_3″ _builder_version=”4.27.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_wc_title _builder_version=”4.27.2″ _module_preset=”default” header_font_size=”27px” custom_margin=”|-164px||||” global_colors_info=”{}”][\/et_pb_wc_title][\/et_pb_column_inner][et_pb_column_inner type=”1_2″ saved_specialty_column_type=”2_3″ _builder_version=”4.27.2″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner _builder_version=”4.27.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_column_inner saved_specialty_column_type=”2_3″ _builder_version=”4.27.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_wc_description admin_label=”Woo Product Short Description” _builder_version=”4.27.4″ custom_margin=”-8px|||||” global_colors_info=”{}”][\/et_pb_wc_description][et_pb_wc_meta show_sku=”off” admin_label=”Woo Product Meta” _builder_version=”4.27.2″ global_colors_info=”{}”][\/et_pb_wc_meta][et_pb_button button_url=”https:\/\/entrogen.com\/web4\/product-information-request-form\/” button_text=”Request More Information” button_alignment=”left” admin_label=”Button” _builder_version=”4.27.4″ _module_preset=”default” custom_button=”on” button_text_size=”13px” button_text_color=”#FFFFFF” button_bg_color=”#476e8d” button_border_color=”RGBA(255,255,255,0)” background_layout=”dark” custom_margin=”30px|||||” global_colors_info=”{}”][\/et_pb_button][\/et_pb_column_inner][\/et_pb_row_inner][\/et_pb_column][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ custom_padding=”0px||||false|false” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” width=”100%” custom_padding=”6px|||||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_tabs admin_label=”Tabs” _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”24px|||||” custom_padding=”|30px|60px|||” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″][et_pb_tab title=”Product Overview” _builder_version=”4.27.4″ _module_preset=”default” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]\n

Fusion genes involving ALK, ROS1, and RET, as well as MET exon 14 skipping mutations, are key oncogenic drivers in non-small cell lung cancer (NSCLC). These genetic alterations result from chromosomal translocations leading to abnormal activation of tyrosine kinase signaling pathways that drive tumor growth. While ALK, ROS1, and RET fusions occur in a subset of NSCLC patients (3-7%, ~2%, and ~1%, respectively), MET exon 14 skipping mutations are detected in 3-4% of lung adenocarcinoma cases. Identifying these alterations is critical, as patients with these mutations may benefit from targeted therapies.<\/p>\n

The Lung Cancer RNA Panel is a one-step RT-qPCR assay designed for the qualitative detection of ALK, ROS1, and RET fusion genes, as well as MET exon 14 skipping mutations. The assay employs a proprietary enzyme\/buffer mix, enabling simultaneous reverse transcription and amplification of target sequences in a single reaction. Using fluorescent probes for precise mutation detection and an endogenous control gene for quality assessment, this panel ensures reliable and high-sensitivity results.<\/p>\n

The kit is optimized <\/span>for use with RNA isolated from tumor biopsies, FFPE samples, and fresh-frozen tissues.<\/p>\n

The Lung Cancer RNA Panel provides a streamlined workflow and highly accurate molecular profiling, making it an essential tool for oncologists, pathologists, and researchers focused on precision medicine in lung cancer.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Fusion Gene Variant<\/strong><\/td>\nChromosomal Translocation<\/strong><\/td>\nPrimer No.<\/strong><\/td>\n<\/tr>\n
EML4-ALK<\/td>\nE13;A20<\/td>\n1<\/td>\n<\/tr>\n
E20;A20<\/td>\n1<\/td>\n<\/tr>\n
E20;ins18A20<\/td>\n1<\/td>\n<\/tr>\n
E6;A20<\/td>\n1<\/td>\n<\/tr>\n
E6ins33;A20<\/td>\n1<\/td>\n<\/tr>\n
E6;ins18A20<\/td>\n1<\/td>\n<\/tr>\n
E14ins11;del49A20<\/td>\n2<\/td>\n<\/tr>\n
E2;A20<\/td>\n3<\/td>\n<\/tr>\n
E2;ins117A20<\/td>\n3<\/td>\n<\/tr>\n
E13;ins69A20<\/td>\n1<\/td>\n<\/tr>\n
E14;del14A20<\/td>\n2<\/td>\n<\/tr>\n
E14;del36A20<\/td>\n2<\/td>\n<\/tr>\n
E17;ins30A20<\/td>\n3<\/td>\n<\/tr>\n
E17ins61;ins34A20<\/td>\n3<\/td>\n<\/tr>\n
E17del58ins39;A20<\/td>\n3<\/td>\n<\/tr>\n
E17ins65;A20<\/td>\n3<\/td>\n<\/tr>\n
E17;ins68A20<\/td>\n3<\/td>\n<\/tr>\n
E15del60;del71A20<\/td>\n2<\/td>\n<\/tr>\n
E18;A20<\/td>\n3<\/td>\n<\/tr>\n
E3;ins53A20<\/td>\n3<\/td>\n<\/tr>\n
E6;A19<\/td>\n1<\/td>\n<\/tr>\n
SLC34A2-ROS1<\/td>\nS4;R32<\/td>\n6<\/td>\n<\/tr>\n
S13del;R32<\/td>\n6<\/td>\n<\/tr>\n
S4;R34<\/td>\n5<\/td>\n<\/tr>\n
S13del;R34<\/td>\n5<\/td>\n<\/tr>\n
CD74-ROS1<\/td>\nC6;R32<\/td>\n6<\/td>\n<\/tr>\n
C7;R32<\/td>\n6<\/td>\n<\/tr>\n
C6;R34<\/td>\n5<\/td>\n<\/tr>\n
SDC4-ROS1<\/td>\nS2;R32<\/td>\n6<\/td>\n<\/tr>\n
S4;R32<\/td>\n6<\/td>\n<\/tr>\n
S4;R34<\/td>\n5<\/td>\n<\/tr>\n
EZR-ROS1<\/td>\nE10;R34<\/td>\n5<\/td>\n<\/tr>\n
LRIG3-ROS1<\/td>\nL16;R35<\/td>\n7<\/td>\n<\/tr>\n
TPM3-ROS1<\/td>\nT8;R35<\/td>\n7<\/td>\n<\/tr>\n
GOPC-ROS1<\/td>\nG7;R35<\/td>\n7<\/td>\n<\/tr>\n
G4;R36<\/td>\n4<\/td>\n<\/tr>\n
KIF5B-RET<\/td>\nK15;R12<\/td>\n4<\/td>\n<\/tr>\n
K16;R12<\/td>\n4<\/td>\n<\/tr>\n
K22;R12<\/td>\n4<\/td>\n<\/tr>\n
K23;R12<\/td>\n4<\/td>\n<\/tr>\n
K24;R8<\/td>\n5<\/td>\n<\/tr>\n
K24;R11<\/td>\n5<\/td>\n<\/tr>\n
K15;R11<\/td>\n7<\/td>\n<\/tr>\n
CCDC6-RET<\/td>\nC1;R12<\/td>\n8<\/td>\n<\/tr>\n
NCOA4-RET<\/td>\nN6;R12<\/td>\n8<\/td>\n<\/tr>\n
TRIM33-RET<\/td>\nT14;R12<\/td>\n8<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n\n
Gene<\/strong><\/td>\nMutation<\/strong><\/td>\nPrimer No.<\/strong><\/td>\n<\/tr>\n
MET<\/td>\nExon 14 Skipping<\/td>\n3<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

For More Information<\/span><\/a><\/p>\n[\/et_pb_tab][et_pb_tab title=”Workflow” _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”]\n

The Lung Cancer RNA Panel follows a streamlined and efficient workflow, allowing for mutation detection in approximately 2 hours with minimal complexity.<\/p>\n

EntroGen\u2019s Lung Cancer RNA Panel requires a real-time PCR instrument capable of detecting FAM, VIC, and CY5 fluorescent probes. The kit includes all necessary reagents for PCR amplification and detection, along with validated reaction controls to ensure reliable results.<\/p>\n

RNA isolation columns and reagents are not included.<\/p>\n

\"\"\"\" \"\"\u00a0\"\" \"\"<\/p>\n[\/et_pb_tab][et_pb_tab title=”Resources” _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”]\n

<\/a><\/p>\n\n\n\n
\"\"<\/a><\/td>\nWebinar Recording:\u00a0 RNA Based NGS & RT-PCR Alternatives for Fusion Gene Detection in Solid Tumors<\/strong><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

Click to download lot-specific quality control data for your product:<\/p>\n

Download<\/span><\/a><\/a><\/u><\/p>\n

 <\/p>\n[\/et_pb_tab][\/et_pb_tabs][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_wc_related_products include_categories=”current” show_price=”off” show_rating=”off” show_sale_badge=”off” _builder_version=”4.27.2″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_wc_related_products][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_section]\n","protected":false},"excerpt":{"rendered":"

Cat Number: LUNG-RT48<\/strong><\/p>\n

The Lung Cancer RNA Panel is a RT-qPCR assay that detects ALK, ROS1, and RET fusion genes, as well as MET exon 14 skipping mutations, which are key oncogenic drivers in non-small cell lung cancer and important for targeted therapy selection.<\/p>\n