Download<\/span><\/a><\/a><\/u><\/p>\n <\/p>\n
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<\/p>\n[\/et_pb_tab][\/et_pb_tabs][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_wc_related_products orderby=”date-desc” include_categories=”current,48,43″ show_price=”off” show_rating=”off” show_sale_badge=”off” _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_wc_related_products][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_section]\n","protected":false},"excerpt":{"rendered":"
Cat Number: BRCAX-NGS<\/strong><\/p>\nThe BRCA Complete\u2122 Expanded Panel is a next-generation sequencing (NGS) assay that enables comprehensive detection of mutations in BRCA1, BRCA2, CHEK2, PALB2, RAD51C, and TP53 genes, offering a powerful tool for hereditary cancer risk assessment and guiding personalized treatment decisions, including PARP inhibitor therapy.<\/p>\n
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\n- Analytical sensitivity as low as 5% MAF<\/li>\n
- Includes reagents for target enrichment; library preparation, clean up, sample and library QC<\/li>\n
- Compatible with Illumina\u00ae NextSeq 500, MiniSeq, and MiSeq sequencers<\/li>\n
- Complimentary data-analysis software for local installation available<\/li>\n
- 40 tests per kit<\/li>\n
- For research use (RUO) in the U.S<\/li>\n
- For in vitro diagnostic use (IVD) in the European Union<\/li>\n<\/ul>\n","protected":false},"featured_media":4899,"template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"[su_tabs][su_tab title=\"Overview\" disabled=\"no\" anchor=\"\" url=\"\" target=\"\" class=\"\"]\r\n\r\nMutations in the KRAS gene, commonly found in metastatic colorectal cancer (mCRC), lung adenocarcinoma, and thyroid cancer, can make tumors resistant to anti-EGFR treatments. Studies show that mutations in exons 2, 3, and 4 of the KRAS and NRAS genes reduce the effectiveness of these therapies, leading experts, including the American Society of Clinical Oncology (ASCO), to recommend genetic screening before treatment.\r\n\r\nThe RAS mutation analysis real-time assay utilizes allele-specific PCR, ensuring accurate detection using fluorescent hydrolysis probes. The panel is a qualitative test that detects somatic mutations found in exons 2, 3, and 4 of KRAS and NRAS genes. Below is a list of mutations detected by this kit.\r\n\r\nThe RAS Mutation Screening Panel identifies the presence of the mutations in a total of 8 reactions per sample. The test does not distinguish between mutations within each group.\r\n\r\n*A complementary add-on reaction that distinguishes KRAS G12C from other codon 12 mutations is available, upon request.\r\n\r\n
![\"\"](\"http:\/\/entrogen.com\/web4\/wp-content\/uploads\/2024\/11\/KRAS-Mutation-Chart-300x128.png\")
\r\n<\/sup>1<\/sup> My Cancer Genome; www.mycancergenome.org (Colorectal Carcinoma, Colorectal Adenocarcinoma)\r\n\r\n[\/su_tab]\r\n[su_tab title=\"Workflow\" disabled=\"no\" anchor=\"\" url=\"\" target=\"blank\" class=\"\"]\r\n\r\nProduct Workflow\r\n\r\n[\/su_tab]\r\n[su_tab title=\"Resources\" disabled=\"no\" anchor=\"\" url=\"\" target=\"blank\" class=\"\"]\r\n\r\n \r\n\r\n \r\n\r\nhttp:\/\/entrogen.com\/web4\/videos\/ras.htm<\/a>\r\n\r\n[\/su_tab][\/su_tabs]","_et_gb_content_width":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false},"product_brand":[],"product_cat":[43],"product_tag":[72],"class_list":{"0":"post-4462","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-breast-ovarian-cancer","7":"product_tag-brca","9":"first","10":"instock","11":"shipping-taxable","12":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/entrogen.com\/web4\/wp-json\/wp\/v2\/product\/4462","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/entrogen.com\/web4\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/entrogen.com\/web4\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/entrogen.com\/web4\/wp-json\/wp\/v2\/media\/4899"}],"wp:attachment":[{"href":"https:\/\/entrogen.com\/web4\/wp-json\/wp\/v2\/media?parent=4462"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/entrogen.com\/web4\/wp-json\/wp\/v2\/product_brand?post=4462"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/entrogen.com\/web4\/wp-json\/wp\/v2\/product_cat?post=4462"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/entrogen.com\/web4\/wp-json\/wp\/v2\/product_tag?post=4462"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
![\"\"](\"https:\/\/entrogen.com\/web4\/wp-content\/uploads\/2025\/04\/BRCAX-NGS-target-enrichment-1.png\")
![\"\"](\"https:\/\/entrogen.com\/web4\/wp-content\/uploads\/2025\/04\/Arrow-right-sized-lower-74x300.png\")
![\"\"](\"https:\/\/entrogen.com\/web4\/wp-content\/uploads\/2025\/04\/BRCAX-NGS-library-prep.png\")
\u00a0![\"\"](\"https:\/\/entrogen.com\/web4\/wp-content\/uploads\/2025\/04\/BRCAX-NGS-sequence.png\")
\u00a0\u00a0![\"\"](\"https:\/\/entrogen.com\/web4\/wp-content\/uploads\/2025\/04\/BRCAX-NGS-analyze-results.png\")
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