{"id":5372,"date":"2026-03-19T17:32:34","date_gmt":"2026-03-19T17:32:34","guid":{"rendered":"https:\/\/entrogen.com\/web4\/?post_type=product&p=5372"},"modified":"2026-04-30T20:59:26","modified_gmt":"2026-04-30T20:59:26","slug":"dpyd-genotyping-kit","status":"publish","type":"product","link":"https:\/\/entrogen.com\/web4\/product\/dpyd-genotyping-kit\/","title":{"rendered":"DPYD Genotyping Kit"},"content":{"rendered":"[et_pb_section fb_built=”1″ admin_label=”Section” _builder_version=”4.27.2″ _module_preset=”default” custom_padding=”6px||4px|||” collapsed=”off” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” width=”100%” custom_padding=”0px||0px||false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_wc_breadcrumb admin_label=”Woo Breadcrumbs” _builder_version=”4.16″ global_colors_info=”{}”][\/et_pb_wc_breadcrumb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ specialty=”on” _builder_version=”4.27.2″ _module_preset=”default” custom_padding=”0px||9px|||” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_wc_images _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”|||-98px||” custom_padding=”|||23px||” global_colors_info=”{}”][\/et_pb_wc_images][\/et_pb_column][et_pb_column type=”2_3″ specialty_columns=”2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_row_inner column_structure=”1_2,1_2″ _builder_version=”4.27.2″ _module_preset=”default” custom_padding=”|0px||||” global_colors_info=”{}”][et_pb_column_inner type=”1_2″ saved_specialty_column_type=”2_3″ _builder_version=”4.27.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_wc_title _builder_version=”4.27.2″ _module_preset=”default” header_font_size=”27px” custom_margin=”|-164px||||” global_colors_info=”{}”][\/et_pb_wc_title][\/et_pb_column_inner][et_pb_column_inner type=”1_2″ saved_specialty_column_type=”2_3″ _builder_version=”4.27.2″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner _builder_version=”4.27.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_column_inner saved_specialty_column_type=”2_3″ _builder_version=”4.27.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_wc_description admin_label=”Woo Product Short Description” _builder_version=”4.27.4″ custom_margin=”-8px|||||” global_colors_info=”{}”][\/et_pb_wc_description][et_pb_wc_meta show_sku=”off” admin_label=”Woo Product Meta” _builder_version=”4.27.2″ global_colors_info=”{}”][\/et_pb_wc_meta][et_pb_button button_url=”https:\/\/entrogen.com\/web4\/product-information-request-form\/” button_text=”Request More Information” button_alignment=”left” admin_label=”Button” _builder_version=”4.27.4″ _module_preset=”default” custom_button=”on” button_text_size=”13px” button_text_color=”#FFFFFF” button_bg_color=”#476e8d” button_border_color=”RGBA(255,255,255,0)” background_layout=”dark” custom_margin=”30px|||||” global_colors_info=”{}”][\/et_pb_button][\/et_pb_column_inner][\/et_pb_row_inner][\/et_pb_column][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ custom_padding=”0px||||false|false” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” width=”100%” custom_padding=”6px|||||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_tabs admin_label=”Tabs” _builder_version=”4.27.6″ _module_preset=”default” custom_margin=”24px|||||” custom_padding=”|30px|60px|||” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″][et_pb_tab title=”Product Overview” _builder_version=”4.27.6″ _module_preset=”default” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]\n

Dihydropyrimidine dehydrogenase (DPD), encoded by the DPYD gene, is the key enzyme responsible for the metabolism of fluoropyrimidine-based therapies such as 5-fluorouracil (5-FU) and capecitabine. Germline variants in DPYD can result in reduced or absent enzyme activity, leading to increased exposure to active drug metabolites and a significantly higher risk of severe, and potentially life-threatening, toxicities. These toxicities may include myelosuppression, gastrointestinal complications, and neurotoxicity, making DPYD genotyping an important tool in pharmacogenomics research.<\/p>\n

The EntroGen DPYD Genotyping Kit is designed to detect DPYD variants associated with reduced enzyme activity. Using a streamlined real-time PCR workflow, the assay enables clear and reliable identification of genetic variants across multiple targets in a single test.<\/p>\n

The table below lists the AMP Tier 1<\/strong> DPYD variants detected by the kit:<\/p>\n\n\n\n\n\n\n\n\n\n\n
DPYD Genomic Position (hg38)<\/strong><\/td>\nDPYD Variant (NM_000110.4)\u00a0<\/strong><\/td>\n<\/tr>\n
\u00a0chr1: 97579893<\/td>\nc.1129-5923C>G<\/td>\n<\/tr>\n
chr1: 97515787<\/td>\nc.1679T>G<\/td>\n<\/tr>\n
chr1: 97305279<\/td>\nc.2279C>T<\/td>\n<\/tr>\n
chr1: 97699474<\/td>\nc.557A>G<\/td>\n<\/tr>\n
chr1: 97595149<\/td>\nc.868A>G<\/td>\n<\/tr>\n
chr1: 97082391<\/td>\nc.2846A>T<\/td>\n<\/tr>\n
chr1: 97450058<\/td>\nc.1905+1G>A<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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The DPYD Genotyping Kit follows a simple and streamlined workflow that can be completed within a standard workday.<\/p>\n

EntroGen\u2019s DPYD Genotyping Kit requires a real-time PCR instrument capable of detecting VIC, FAM, and CY5 fluorescent probes.<\/p>\n

This assay includes all reagents necessary for multiplex PCR amplification and detection, along with validated controls, including a homozygous variant control, homozygous wild-type control, and a reference calibrator to support accurate genotype determination.<\/p>\n

Reagents for genomic DNA extraction are not included. High-quality genomic DNA can be isolated using commercially available extraction kits.<\/p>\n

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 <\/p>\n

Click to download lot-specific quality control data for your product:<\/p>\n

Download<\/span><\/a><\/a><\/u><\/p>\n

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Cat Number: DPYD-RT26<\/strong><\/p>\n

The DPYD Genotyping Kit is a real-time PCR-based assay that detects germline variants in the DPYD gene, which are associated with reduced dihydropyrimidine dehydrogenase activity.<\/p>\n

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