{"id":5399,"date":"2026-04-22T20:34:45","date_gmt":"2026-04-22T20:34:45","guid":{"rendered":"https:\/\/entrogen.com\/web4\/?post_type=product&p=5399"},"modified":"2026-04-30T20:37:05","modified_gmt":"2026-04-30T20:37:05","slug":"ugt1a1-genotyping-kit","status":"publish","type":"product","link":"https:\/\/entrogen.com\/web4\/product\/ugt1a1-genotyping-kit\/","title":{"rendered":"UGT1A1 Genotyping Kit"},"content":{"rendered":"[et_pb_section fb_built=”1″ admin_label=”Section” _builder_version=”4.27.2″ _module_preset=”default” custom_padding=”6px||4px|||” collapsed=”off” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” width=”100%” custom_padding=”0px||0px||false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_wc_breadcrumb admin_label=”Woo Breadcrumbs” _builder_version=”4.16″ global_colors_info=”{}”][\/et_pb_wc_breadcrumb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ specialty=”on” _builder_version=”4.27.2″ _module_preset=”default” custom_padding=”0px||9px|||” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_wc_images _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”|||-98px||” custom_padding=”|||23px||” global_colors_info=”{}”][\/et_pb_wc_images][\/et_pb_column][et_pb_column type=”2_3″ specialty_columns=”2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_row_inner column_structure=”1_2,1_2″ _builder_version=”4.27.2″ _module_preset=”default” custom_padding=”|0px||||” global_colors_info=”{}”][et_pb_column_inner type=”1_2″ saved_specialty_column_type=”2_3″ _builder_version=”4.27.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_wc_title _builder_version=”4.27.2″ _module_preset=”default” header_font_size=”27px” custom_margin=”|-164px||||” global_colors_info=”{}”][\/et_pb_wc_title][\/et_pb_column_inner][et_pb_column_inner type=”1_2″ saved_specialty_column_type=”2_3″ _builder_version=”4.27.2″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner _builder_version=”4.27.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_column_inner saved_specialty_column_type=”2_3″ _builder_version=”4.27.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_wc_description admin_label=”Woo Product Short Description” _builder_version=”4.27.4″ custom_margin=”-8px|||||” global_colors_info=”{}”][\/et_pb_wc_description][et_pb_wc_meta show_sku=”off” admin_label=”Woo Product Meta” _builder_version=”4.27.2″ global_colors_info=”{}”][\/et_pb_wc_meta][et_pb_button button_url=”https:\/\/entrogen.com\/web4\/product-information-request-form\/” button_text=”Request More Information” button_alignment=”left” admin_label=”Button” _builder_version=”4.27.4″ _module_preset=”default” custom_button=”on” button_text_size=”13px” button_text_color=”#FFFFFF” button_bg_color=”#476e8d” button_border_color=”RGBA(255,255,255,0)” background_layout=”dark” custom_margin=”30px|||||” global_colors_info=”{}”][\/et_pb_button][\/et_pb_column_inner][\/et_pb_row_inner][\/et_pb_column][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ custom_padding=”0px||||false|false” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” width=”100%” custom_padding=”6px|||||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_tabs admin_label=”Tabs” _builder_version=”4.27.6″ _module_preset=”default” custom_margin=”24px|||||” custom_padding=”|30px|60px|||” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″][et_pb_tab title=”Product Overview” _builder_version=”4.27.6″ _module_preset=”default” global_colors_info=”{}”]\n

Uridine diphosphate-glucuronyl transferase 1A1 (UGT1A1) is an enzyme that catalyzes the glucuronidation of various compounds, including steroid hormones, bilirubin, as well as xenobiotics, such as irinotecan.\u00a0 Genetic variation in the promoter region of the UGT1A1 gene, most commonly the UGT1A1*28 allele, results in reduced transcriptional activity and decreased enzyme expression. This can lead to impaired detoxification capacity and increased susceptibility to drug-related toxicity.<\/p>\n

The EntroGen UGT1A1 Genotyping Kit is designed to detect and differentiate the UGT1A11 (TA)6 and UGT1A1<\/em>28 (TA)7 promoter polymorphisms in human genomic DNA. Using a streamlined real-time PCR workflow with allelic discrimination technology, the assay enables clear and reliable identification of UGT1A1 genotypes in a single test.<\/p>\n[\/et_pb_tab][et_pb_tab title=”Workflow” _builder_version=”4.27.6″ _module_preset=”default” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]\n

The UGT1A1 Genotyping Kit follows a simple and easy-to-use real-time PCR workflow that can be completed in approximately 2 hours, enabling rapid allelic discrimination in a streamlined format.<\/p>\n

EntroGen\u2019s UGT1A1 Genotyping Kit requires a real-time PCR instrument capable of detecting FAM and VIC fluorescent probes for accurate allelic discrimination of UGT1A*11 and UGT1A1*<\/em>28 variants.<\/p>\n

This assay includes all reagents required for PCR amplification and detection, along with validated wild-type and variant control materials to ensure reliable genotype calling and run performance.<\/p>\n

Reagents and consumables for genomic DNA extraction are not included. Genomic DNA can be isolated from whole blood or other human samples using commercially available extraction methods, such as the EntroGen pureNA\u00ae Genomic DNA Isolation Kit.<\/a><\/p>\n

\"\"\"\"\"\"\"\"\"\"<\/p>\n[\/et_pb_tab][et_pb_tab title=”Resources” _builder_version=”4.27.6″ _module_preset=”default” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]\n

 <\/p>\n\n\n\n\n
\"\"<\/a><\/td>\nThe frequency, clinical course, and health related quality of life in adults with Gilbert\u2019s syndrome: a longitudinal study.<\/strong> Kamal S, Abdelhakam S, Ghoraba D, Massoud Y, Aziz KA, Hassan H, Hafez T, Abdel Sallam A. BMC gastroenterology. 2019 Feb 4;19(1):22.<\/a><\/td>\n<\/tr>\n
\"\"<\/a><\/td>\nOral administration of irinotecan in patients with solid tumors: an open-label, phase I, dose escalating study evaluating safety, tolerability and pharmacokinetics.<\/strong> K\u00fcmler I, S\u00f8rensen PG, Palshof J, H\u00f8gdall E, Skovrider-Ruminski W, Theile S, Fullerton A, Nielsen PG, Jensen BV, Nielsen DL. Cancer chemotherapy and pharmacology. 2019 Jan 31;83(1):169-78.<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

Click to download lot-specific quality control data for your product:<\/p>\n

Download<\/span><\/a><\/a><\/u><\/p>\n

 <\/p>\n[\/et_pb_tab][\/et_pb_tabs][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_wc_related_products _builder_version=”4.27.6″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_wc_related_products][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.27.6″ _module_preset=”default” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.6″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.6″ _module_preset=”default” global_colors_info=”{}”][et_pb_image _builder_version=”4.27.6″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section]\n","protected":false},"excerpt":{"rendered":"

Cat Number: UGT-RT50<\/strong><\/p>\n

The UGT1A1 Genotyping Kit is a real-time PCR assay for differentiation of UGT1A1*1 and *28 polymorphisms in human genomic DNA.<\/p>\n

 <\/p>\n