GIST Mutation Detection Kit
Available Products
| Product Name/Description |
No. of Reactions*
|
Product Code |
|---|---|---|
| GIST Mutation Detection Kit for Real-Time PCR |
44
|
GIST-RT44 |
*Includes all controls.
| PDGFRA & c-KIT Mutations in GIST Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the GI tract. Over 80% of GISTs harbor activating mutation in c-KIT and approximately 5-7% in PDGFRA. Although these mutations cause tumorigenesis, they also predict response to targeted therapies and provide prognostic information.The GIST Mutation Screening Panel detects the following mutations:
Testing Procedure and Analysis EntroGen’s GIST mutation screening panel is a polymerase chain reaction (PCR)-based assay that uses allele-specific primers to identify the presence of somatic mutations in c-KIT and PDGFRA genes. The testing procedure involves three (3) simple steps:
This test can be completed in approximately 2 hours from isolation of DNA to test result. Equipment and Materials EntroGen’s GIST mutation screening panel requires a real-time PCR instrument capable of detecting FAM, VIC, ROX and CY5 fluorescent probes. This test includes reagents required for the PCR amplification/detection, as well as validated reaction controls. Columns and reagents for DNA isolation are not included. Intended Use USA: Available for research use only (RUO). Not for use in diagnostic procedures. Europe: Available for research (RUO) and diagnostic (CE-IVD) purposes.
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